Structure Information

PDB: 9NA4 ‍
Resolution: 2.33 Å
Method: X-ray diffraction
Organism: Homo sapiens

Publication

Discovery of Edecesertib (GS-5718): A Potent, Selective Inhibitor of IRAK4.

Ammann, S.E., Cottell, J.J., Wright, N.E., Warr, M.R., Snyder, C.A., Bacon, E.M., Brizgys, G., Chin, E., Chou, C., Conway, A., Dick, R.A., Ferrao, R.D., Garrison, K.L., Hammond, A., Lansdon, E.B., Link, J.O., Mukherjee, P.K., Murray, B.P., Mwangi, J., Ndukwe, M.S., Park, G.Y., Serone, A.P., Suekawa-Pirrone, K., Yang, Z.Y., Zipfel, S.M., Taylor, J.G. (2025) J Med Chem 68: 10619-10630
DOI: https://doi.org/10.1021/acs.jmedchem.5c00463